Programme at a Glance

Date Title of the session Chair

Sunday  9 September 2018
18.00 - 19.30 Plenary lectures
Patrick Masson
Kamil Kuca
19.30 - 21.00 Welcome party  

Monday  10 September 2018
08.15 - 08.30 Opening ceremony  
08.30 - 11.30 Structure and dynamics of cholinesterases and OP hydrolases Yuan-Ping Pang
Joel Sussman
11.30 - 12.30 Lunch  
12.30 - 15.15 Interaction of cholinesterases with substrates, inhibitors and reactivators Terrone Rosenberry
Franz Worek
15.40 - 18.10 Reactivators of AChE, OP inhibitors - mechanism of toxicity, detection
and analytical methods, diagnosis of exposure, detoxification and therapy;
counter-terrorism strategies
Franz Worek
Terrone Rosenberry

Tuesday  11 September 2018
08.00 - 09.40 Enzymes and proteins other than ChEs interacting with OP Oksana Lockridge
Patrick Masson
10.00 - 12.10 Stoichiometric bioscavangers, biotechnology and therapeutical aspects Palmer Taylor
12.10 - 13.40 Lunch  
13.40 - 16.00 Catalytical Bioscavangers - PON and PTE I Eugenio Vilanova
Florian Nachon
18.00 Walking tour around the city  
20.00 Concert in the Cathedral of the Holy Spirit                                        

Wednesday  12 September 2018
08.30 - 11.30 3D section - structure and dynamics of α/β hydrolases and OP hydrolases,
in silico methods for designing of modulator
Zoran Radić
Jonah Cheung
11.30 - 13.00 Lunch  
13.00 Trips  

Thursday  13 September 2018
08.00 - 11.30 Biological functions, development and non-cholinergic function
of cholinesterases
Shani Shenhar-Tsarfaty
Israel Silman
11.30 - 12.30 Lunch  
12.30 - 14.45 Alzheimer's disease and diseases related to cholinesterases Ana Martinez
Maria-Laura Bolognesi
15.10 - 17.40 Multi-target-directed ligands in Alzheimer's disease primarily targeting
cholinesterases
Maria-Laura Bolognesi
Ana Martinez
20.00 Gala dinner  

Friday  14 September 2018
08.00 - 09.20 Varia Kamil Kuca
Ondrej Soukup
09.20 - 09.30 Concluding remarks  
10.00 Shuttle bus to Prague Airport